Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: A meta-analysis.

ABSTRACT:

Objective

To determine associations between cerebral microbleed (CMB) burden with recurrent ischemic stroke (IS) and intracerebral hemorrhage (ICH) risk after IS or TIA.

Methods

We identified prospective studies of patients with IS or TIA that investigated CMBs and stroke (ICH and IS) risk during ≥3 months follow-up. Authors provided aggregate summary-level data on stroke outcomes, with CMBs categorized according to burden (single, 2-4, and ≥5 CMBs) and distribution. We calculated absolute event rates and pooled risk ratios (RR) using random-effects meta-analysis.

Results

We included 5,068 patients from 15 studies. There were 115/1,284 (9.6%) recurrent IS events in patients with CMBs vs 212/3,781 (5.6%) in patients without CMBs (pooled RR 1.8 for CMBs vs no CMBs; 95%

SUBMITTER: Wilson D 

PROVIDER: S-EPMC5075978 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature