Bloch-Siegert B1+-mapping for human cardiac (31) P-MRS at 7 Tesla.

ABSTRACT:

Purpose

Phosphorus MR spectroscopy ((31) P-MRS) is a powerful tool for investigating tissue energetics in vivo. Cardiac (31) P-MRS is typically performed using surface coils that create an inhomogeneous excitation field across the myocardium. Accurate measurements of B1+ (and hence flip angle) are necessary for quantitative analysis of (31) P-MR spectra. We demonstrate a Bloch-Siegert B1+-mapping method for this purpose.

Theory and methods

We compare acquisition strategies for Bloch-Siegert B1+-mapping when there are several spectral peaks. We optimize a Bloch-Siegert sensitizing (Fermi) pulse for cardiac (31) P-MRS at 7 Tesla (T) and apply it in a three-dimensional (3D) chemical shift imaging sequence. We validate this in phantoms and skeletal muscle (against a dual-TR meth

SUBMITTER: Clarke WT 

PROVIDER: S-EPMC5076794 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature