Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain.

ABSTRACT:

Background

Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors.

Methods

In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models.

Results

Our results show an inverse association of age a

SUBMITTER: Lope V 

PROVIDER: S-EPMC5077095 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature