Top-Down Network Effective Connectivity in Abstinent Substance Dependent Individuals.

ABSTRACT:

Objective

We hypothesized that compared to healthy controls, long-term abstinent substance dependent individuals (SDI) will differ in their effective connectivity between large-scale brain networks and demonstrate increased directional information from executive control to interoception-, reward-, and habit-related networks. In addition, using graph theory to compare network efficiencies we predicted decreased small-worldness in SDI compared to controls.

Methods

50 SDI and 50 controls of similar sex and age completed psychological surveys and resting state fMRI. fMRI results were analyzed using group independent component analysis; 14 networks-of-interest (NOI) were selected using template matching to a canonical set of resting state networks. The number, direction, and stre

SUBMITTER: Regner MF 

PROVIDER: S-EPMC5077096 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature