Risk of Premenopausal and Postmenopausal Breast Cancer among Multiple Sclerosis Patients.

ABSTRACT:

Objective

To investigate risk of premenopausal and postmenopausal breast cancer among Multiple Sclerosis (MS) patients, considering tumor stage.

Methods

The Swedish Patient Register identified 19,330 women with MS between 1968 and 2012, matched individually with a cohort of 193,458 without MS. Matching variables were year of birth, sex, region of residence and vital status at the time of diagnosis. The cancer register identified 471 and 5,753 breast cancer cases among the MS and non-MS cohorts, respectively. Cox proportional hazard models estimated hazard ratios (HR) and 95% confidence intervals (CI) for premenopausal and postmenopausal breast cancer.

Results

Overall risk of postmenopausal breast cancer was 13% higher among MS patients compared with women without MS (

SUBMITTER: Hajiebrahimi M 

PROVIDER: S-EPMC5077134 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature