The CD47 "don't eat me signal" is highly expressed in human ovarian cancer.

ABSTRACT:

Objectives

The CD47 "don't eat me" signal allows tumor immune evasion. We tested the association of CD47 expression with outcomes in EOC.

Methods

CD47 expression was examined within the TCGA database for ovarian carcinoma. For validation, IHC was performed on a TMA consisting of specimens from 265 patients with EOC. The medical records of the patients were also retrospectively reviewed to correlate demographic and survival data.

Results

CD47 was amplified in 15/316 (5%) ovarian serous cancers in TCGA. In the validation cohort, the majority of patients had stage III/IV disease (208/265, 78.4%). CD47 expression was seen in 210/265 (79.2%). Patients were categorized into CD47hi (129/265; 48.7%) versus CD47lo (136/265; 51.3%). Patients with CD47lo tumors were more likely

SUBMITTER: Brightwell RM 

PROVIDER: S-EPMC5077667 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature