Cost-effective management of women with minor cervical lesions: Revisiting the application of HPV DNA testing.

ABSTRACT:

Background

Lack of consensus in management guidelines for women with minor cervical lesions, coupled with novel screening approaches, such as human papillomavirus (HPV) genotyping, necessitate revisiting prevention policies. We evaluated the cost-effectiveness and resource trade-offs of alternative triage strategies to inform cervical cancer prevention in Norway.

Methods

We used a decision-analytic model to compare the lifetime health and economic consequences associated with ten novel candidate approaches to triage women with minor cervical lesions. Candidate strategies varied by: 1) the triage test(s): HPV testing in combination with cytology, HPV testing alone with or without genotyping for HPV-16 and -18, and immediate colposcopy, and 2) the length of time between index

SUBMITTER: Pedersen K 

PROVIDER: S-EPMC5077685 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature