Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.

ABSTRACT: The histopathological and molecular heterogeneity of glioblastomas represents a major obstacle for effective therapies. Glioblastomas do not develop autonomously, but evolve in a unique environment that adapts to the growing tumour mass and contributes to the malignancy of these neoplasms. Here, we show that patient-derived glioblastoma xenografts generated in the mouse brain from organotypic spheroids reproducibly give rise to three different histological phenotypes: (i) a highly invasive phenotype with an apparent normal brain vasculature, (ii) a highly angiogenic phenotype displaying microvascular proliferation and necrosis and (iii) an intermediate phenotype combining features of invasion and vessel abnormalities. These phenotypic differences were visible during early phases of tumour

SUBMITTER: Bougnaud S 

PROVIDER: S-EPMC5077988 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature