Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17.

ABSTRACT:

Introduction

Intraoperative fluorescence imaging of the folate-receptor alpha (FRα) could support completeness of resection in cancer surgery. Feasibility of EC17, a FRα-targeting agent that fluoresces at 500nm, was demonstrated in a limited series of ovarian cancer patients. Our objective was to evaluate EC17 in a larger group of ovarian cancer patients. In addition, we assessed the feasibility of EC17 in patients with breast cancer.

Methods

Two-to-three hours before surgery 0.1mg/kg EC17 was intravenously administered to 12 patients undergoing surgery for ovarian cancer and to 3 patients undergoing surgery for biopsy-proven FRα-positive breast cancer. The number of lesions/positive margins detected with fluorescence and concordance between fluorescence and tumor- and FRα-s

SUBMITTER: Tummers QR 

PROVIDER: S-EPMC5078003 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature