Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.

ABSTRACT: Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. For its clinical course, host genetic factors are important and rare genomic variants are suspected to contribute. We sequenced the exomes of 59 Greek and 15 German patients with bacterial sepsis divided into two groups with extremely different disease courses. Variant analysis was focusing on rare deleterious single nucleotide variants (SNVs). We identified significant differences in the number of rare deleterious SNVs per patient between the ethnic groups. Classification experiments based on the data of the Greek patients allowed discrimination between the disease courses with estimated sensitivity and specificity>75%. By application of the trained model to the German patients we observed co

SUBMITTER: Taudien S 

PROVIDER: S-EPMC5078585 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature