The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.

ABSTRACT: Reduction in testosterone levels in men during aging is associated with cognitive decline and risk of dementia. Animal studies have shown benefits for testosterone supplementation in improving cognition and reducing Alzheimer's disease pathology. In a randomized, placebo-controlled, crossover study of men with subjective memory complaint and low testosterone levels, we investigated whether testosterone treatment significantly improved performance on various measures of cognitive functioning. Forty-four men were administered a battery of neuropsychological tests to establish the baseline prior to being randomly divided into two groups. The first group (Group A) received 24 weeks of testosterone treatment (T treatment) followed by 4 weeks washout, and then 24 weeks of placebo (P); the second

SUBMITTER: Wahjoepramono EJ 

PROVIDER: S-EPMC5078598 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature