Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1.

ABSTRACT: Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the stomach in response to CR and regulates energy metabolism. We hypothesized that in CR ghrelin has a role in protecting aging-related diseases. We examined the physiological mechanisms underlying the ghrelin system during the aging process in three mouse strains with different genetic and biochemical backgrounds as animal models of accelerated or normal human aging. The elevated plasma ghrelin concentration was observed in both klotho-deficient and senescence-accelerated mouse prone/8 (SAMP8) mice. Ghrelin treatment failed to stimulate appetite and prolong survival in klotho-deficient mice, suggesting the existence of ghrelin resista

SUBMITTER: Fujitsuka N 

PROVIDER: S-EPMC5078860 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature