Draft genome sequence of Streptomyces sp. TP-A0867, an alchivemycin producer.

ABSTRACT: Streptomyces sp. TP-A0867 (=NBRC 109436) produces structurally complex polyketides designated alchivemycins A and B. Here, we report the draft genome sequence of this strain together with features of the organism and assembly, annotation, and analysis of the genome sequence. The 9.9 Mb genome of Streptomyces sp. TP-A0867 encodes 8,385 putative ORFs, of which 7,232 were assigned with COG categories. We successfully identified a hybrid polyketide synthase (PKS)/ nonribosomal peptide synthetase (NRPS) gene cluster that could be responsible for alchivemycin biosynthesis, and propose the biosynthetic pathway. The alchivemycin biosynthetic gene cluster is also present in Streptomyces rapamycinicus NRRL 5491^T, Streptomyces hygroscopicus subsp. hygroscopicus

SUBMITTER: Komaki H 

PROVIDER: S-EPMC5078962 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature