Aging is Associated With an Earlier Arrival of Reflected Waves Without a Distal Shift in Reflection Sites.

ABSTRACT: Despite pronounced increases in central pulse wave velocity (PWV) with aging, reflected wave transit time (RWTT), traditionally defined as the timing of the inflection point (TINF) in the central pressure waveform, does not appreciably decrease, leading to the controversial proposition of a "distal-shift" of reflection sites. TINF, however, is exceptionally prone to measurement error and is also affected by ejection pattern and not only by wave reflection. We assessed whether RWTT, assessed by advanced pressure-flow analysis, demonstrates the expected decline with aging. We studied a sample of unselected adults without cardiovascular disease (n=48; median age 48 years) and a clinical population of older adults with suspected/established cardiovascular disease (n=164; 61 years). We measured

SUBMITTER: Phan TS 

PROVIDER: S-EPMC5079032 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature