Irisin Inhibits Atherosclerosis by Promoting Endothelial Proliferation Through microRNA126-5p.

ABSTRACT: Irisin is a newly discovered myokine that has been considered a promising candidate for the treatment of cardiovascular disease through improving endothelial function. However, little is known about the role of irisin in the progression of atherosclerosis. We used a carotid partial ligation model of apolipoprotein E-deficient mice fed on a high-cholesterol diet to test the anti-atherosclerosis effect of irisin. Irisin treatment significantly suppressed carotid neointima formation. It was associated with increased endothelial cell proliferation. In addition, irisin promoted human umbilical vein endothelial cell survival via upregulating microRNA126-5p expression through the ERK signaling pathway. Inhibition of microRNA126-5p using the microRNA126-5p inhibitor abolished the prosurvival effec

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5079047 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature