Collaborative Modeling of the Benefits and Harms Associated With Different U.S. Breast Cancer Screening Strategies.

ABSTRACT:

Background

Controversy persists about optimal mammography screening strategies.

Objective

To evaluate screening outcomes, taking into account advances in mammography and treatment of breast cancer.

Design

Collaboration of 6 simulation models using national data on incidence, digital mammography performance, treatment effects, and other-cause mortality.

Setting

United States.

Patients

Average-risk U.S. female population and subgroups with varying risk, breast density, or comorbidity.

Intervention

Eight strategies differing by age at which screening starts (40, 45, or 50 years) and screening interval (annual, biennial, and hybrid [annual for women in their 40s and biennial thereafter]). All strategies assumed 100% adherence and stopped at age 74 yea

SUBMITTER: Mandelblatt JS 

PROVIDER: S-EPMC5079106 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature