Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies.

ABSTRACT:

Objectives

Polymyxin B is being increasingly utilized as a last resort against resistant Gram-negative bacteria. We examined the pharmacodynamics of novel dosing strategies for polymyxin B combinations to maximize efficacy and minimize the emergence of resistance and drug exposure against Acinetobacter baumannii.

Methods

The pharmacodynamics of polymyxin B together with doripenem were evaluated in time-kill experiments over 48 h against 10⁸ cfu/mL of two polymyxin-heteroresistant A. baumannii isolates (ATCC 19606 and N16870). Pharmacokinetic/pharmacodynamic relationships were mathematically modelled using S-ADAPT. A hollow-fibre infection model (HFIM) was also used to simulate clinically relevant polymyxin B dosing strategies (traditional, augmented 'front-loaded'

SUBMITTER: Rao GG 

PROVIDER: S-EPMC5079300 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature