Functional Diversity of Cytomegalovirus-Specific T Cells Is Maintained in Older People and Significantly Associated With Protein Specificity and Response Size.

ABSTRACT:

Background

 Parallel upregulation of several T-cell effector functions (ie, polyfunctionality) is believed to be critical for the protection against viruses but thought to decrease in large T-cell expansions, in particular at older ages. The factors determining T-cell polyfunctionality are incompletely understood. Here we revisit the question of cytomegalovirus (CMV)-specific T-cell polyfunctionality, including a wide range of T-cell target proteins, response sizes, and participant ages.

Methods

 Polychromatic flow cytometry was used to analyze the functional diversity (ie, CD107, CD154, interleukin 2, tumor necrosis factor, and interferon γ expression) of CD4⁺ and CD8⁺ T-cell responses to 19 CMV proteins in a large group of young and older United Kingd

SUBMITTER: Bajwa M 

PROVIDER: S-EPMC5079367 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature