Dataset Information

Chronic Hepatitis C Virus Infection and the Proinflammatory Effects of Injection Drug Use.

ABSTRACT:

Background

Chronic inflammation, as defined by persistent immune activation, is associated with adverse clinical outcomes. People who inject drugs (PWID) have evidence of persistent immune activation. Here, in a cohort of PWID with or without hepatitis C virus (HCV) infection, we sought to dissect out the contribution of chronic HCV infection (common in PWID) from the effects of injection drug use itself.

Methods

Four groups of study volunteers were recruited: group 1 comprised active PWID; group 2, individuals who ceased injecting drugs 1-2 months before recruitment; group 3, individuals who ceased injecting drugs 3-4 months before recruitment; and group 4, healthy volunteers. Soluble and cell-associated markers of immune activation were quantified.

Results

HCV-viremic PWID have elevated levels of immune activation when compared to healthy volunteers. Cessation of injection drug use results in a decline in immune activation in the absence of HCV viremia, while HCV-viremic individuals who previously were PWID continue to harbor elevated levels of immune activation, as defined by increased levels of soluble CD14 and tumor necrosis factor α and by the presence of CD38⁺HLA-DR⁺ CD4⁺ and CD8⁺ T cells.

Conclusions

Immune activation, a well-defined surrogate of poor clinical outcome that is elevated in PWID, can regress to normal levels in former injection drug users who are HCV aviremic. Therefore, enhanced harm-reduction efforts should incorporate aggressive treatment of HCV infection.

Clinical trials registration

NCT01831284.

SUBMITTER: Markowitz M

PROVIDER: S-EPMC5079368 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Chronic Hepatitis C Virus Infection and the Proinflammatory Effects of Injection Drug Use.

Markowitz Martin M Deren Sherry S Cleland Charles C La Mar Melissa M Silva Evelyn E Batista Pedro P St Bernard Leslie L Gettie Natanya N Rodriguez Kristina K Evering Teresa H TH Lee Haekyung H Mehandru Saurabh S

The Journal of infectious diseases 20160811 9

<h4>Background</h4> Chronic inflammation, as defined by persistent immune activation, is associated with adverse clinical outcomes. People who inject drugs (PWID) have evidence of persistent immune activation. Here, in a cohort of PWID with or without hepatitis C virus (HCV) infection, we sought to dissect out the contribution of chronic HCV infection (common in PWID) from the effects of injection drug use itself.<h4>Methods</h4> Four groups of study volunteers were recruited: group 1 comprised ...[more]

PMID: 27521361

Similar Datasets

Project description:BackgroundAlthough drug use stigma is globally pervasive, quantitative evidence of its role in hepatitis C virus (HCV) transmission is limited. We evaluated the psychometric properties of a drug use stigma scale and examined the association between drug use stigma and active HCV infection among a community-based sample of people who inject drugs (PWID) in India.MethodsBetween 8/2016 and 5/2017, a cross-sectional sample of PWID was recruited from 12 Indian cities (~1000/city) using respondent-driven sampling. Participants were ≥18 years old and reported injection drug use (IDU) in the past 2 years. Multivariable logistic regression with a random-intercept for each city was used to estimate adjusted odds ratios (aOR) of active HCV infection (RNA>30 IU/mL). Analyses incorporated RDS-II weights.ResultsOf 11,663 participants, 73.1% reported IDU in the past 6 months and 33.8% had active HCV infection. Exploratory factor analysis yielded a four-factor solution of enacted, vicarious, felt normative and internalized drug use stigma with high internal consistency (Cronbach's α: 0.85-0.92). In analyses adjusted for age, gender, northeast region, education, homelessness, incarceration, alcohol dependence, HIV status, frequency of IDU, and ever sharing needles/syringes, PWID reporting any enacted stigma had greater odds of active HCV infection (aOR = 1.27 [95% CI = 1.13-1.43]) as did PWID with internalized stigma scores in the highest quartile (vs. lowest quartile; aOR = 1.69 [95% CI = 1.11-2.56]). Among PWID who reported IDU in the past 6 months, multiple forms of stigma were associated with higher frequency of IDU, sharing needles/syringes, having multiple injection partners, and IDU in public spaces.ConclusionUsing a multidimensional drug use stigma scale, various forms of stigma were significantly associated with active HCV infection and injection drug use-related risk behaviors. Collectively, these data suggest that drug use stigma may play a role in HCV transmission and impede efforts to achieve HCV elimination. Strategies to diminish drug use stigma are warranted.

Dataset Information

Chronic Hepatitis C Virus Infection and the Proinflammatory Effects of Injection Drug Use.

Background

Methods

Results

Conclusions

Clinical trials registration

Publications

Chronic Hepatitis C Virus Infection and the Proinflammatory Effects of Injection Drug Use.

Similar Datasets

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