Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection.

ABSTRACT:

Background

 This study tests the hypothesis that increased elastolytic activity is associated differentially with dolichoectasia in individuals with and those without human immunodeficiency virus (HIV) infection.

Methods

 Large arteries from 84 autopsied brains from HIV-positive individuals and 78 autopsied brains from HIV-negative individuals were stained for metalloproteinase 2 (MMP-2), MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP-2, CD68, and caspase 3. Average pixel intensity was automatically obtained and categorized as high, moderate, or low. Dolichoectasia was defined as a lumen to wall ratio ≥95th percentile.

Results

 High MMP-9 staining alone (P = .001) or coexistent with low TIMP-2 staining was associated with dolichoectasia only in

SUBMITTER: Gutierrez J 

PROVIDER: S-EPMC5079372 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature