Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia.

ABSTRACT:

Background

 Bayesian evolutionary analysis (coalescent analysis) based on genetic sequences has been used to describe the origins and spread of rapidly mutating RNA viruses, such as influenza, Ebola, human immunodeficiency virus (HIV), and hepatitis C virus (HCV).

Methods

 Full-length subtype 1a and 3a sequences from early HCV infections from the International Collaborative of Incident HIV and Hepatitis C in Injecting Cohorts (InC3), as well as from public databases from a time window of 1977-2012, were used in a coalescent analysis with BEAST software to estimate the origin and progression of the HCV epidemics in Australia and North America. Convergent temporal trends were sought via independent epidemiological modeling.

Results

 The epidemic of subtype 3a had more r

SUBMITTER: Rodrigo C 

PROVIDER: S-EPMC5079374 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature