Towards the knowledge-based design of universal influenza epitope ensemble vaccines.

ABSTRACT:

Motivation

Influenza A viral heterogeneity remains a significant threat due to unpredictable antigenic drift in seasonal influenza and antigenic shifts caused by the emergence of novel subtypes. Annual review of multivalent influenza vaccines targets strains of influenza A and B likely to be predominant in future influenza seasons. This does not induce broad, cross protective immunity against emergent subtypes. Better strategies are needed to prevent future pandemics. Cross-protection can be achieved by activating CD8+ and CD4+ T cells against highly conserved regions of the influenza genome. We combine available experimental data with informatics-based immunological predictions to help design vaccines potentially able to induce cross-protective T-cells against multiple influenza s

SUBMITTER: Sheikh QM 

PROVIDER: S-EPMC5079473 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature