AMIGO2, a toolbox for dynamic modeling, optimization and control in systems biology.

ABSTRACT:

Motivation

Many problems of interest in dynamic modeling and control of biological systems can be posed as non-linear optimization problems subject to algebraic and dynamic constraints. In the context of modeling, this is the case of, e.g. parameter estimation, optimal experimental design and dynamic flux balance analysis. In the context of control, model-based metabolic engineering or drug dose optimization problems can be formulated as (multi-objective) optimal control problems. Finding a solution to those problems is a very challenging task which requires advanced numerical methods.

Results

This work presents the AMIGO2 toolbox: the first multiplatform software tool that automatizes the solution of all those problems, offering a suite of state-of-the-art (multi-objective)

SUBMITTER: Balsa-Canto E 

PROVIDER: S-EPMC5079478 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature