A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation.

ABSTRACT: Finding the specific nucleotides that underlie adaptive variation is a major goal in evolutionary biology, but polygenic traits pose a challenge because the complex genotype-phenotype relationship can obscure the effects of individual alleles. However, natural selection working in large wild populations can shift allele frequencies and indicate functional regions of the genome. Previously, we showed that the two most common alleles of a complex amino acid insertion-deletion polymorphism in the Drosophila insulin receptor show independent, parallel clines in frequency across the North American and Australian continents. Here, we report that the cline is stable over at least a five-year period and that the polymorphism also demonstrates temporal shifts in allele frequency concurrent with sea

SUBMITTER: Paaby AB 

PROVIDER: S-EPMC5079517 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature