Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.

ABSTRACT: In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC₅₀ values that are in the same range as of Sofosbuvir.

SUBMITTER: Maiti M 

PROVIDER: S-EPMC5079539 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature