The Specific α1-Adrenergic Receptor Antagonist Prazosin Influences the Urine Proteome.

ABSTRACT: Urine, reflecting many changes in the body, is a better source than blood for biomarker discovery. However, even under physiological conditions, the urine proteome often varies. Understanding how various regulating factors affect urine proteome helps link changes to urine proteome with urinary biomarkers of physiological conditions as well as corresponding diseases. To evaluate the possible impact of α1-adrenergic receptor on urine proteome, this study investigated effects of the specific inhibitor prazosin on the urine proteome in a rat model by using tandem mass tagging and two-dimensional liquid chromatography-tandem mass spectrometry. A total of 775 proteins were identified, approximately half of which were influenced by prazosin treatment, indicating that the sympathetic nervous syste

SUBMITTER: Zhao M 

PROVIDER: S-EPMC5079574 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature