The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life.

ABSTRACT: A drug's biological half-life is defined as the time required for the human body to metabolize or eliminate 50% of the initial drug dosage. Correctly measuring the half-life of a given drug is helpful for the safe and accurate usage of the drug. In this study, we investigated which gene ontology (GO) terms and biological pathways were highly related to the determination of drug half-life. The investigated drugs, with known half-lives, were analyzed based on their enrichment scores for associated GO terms and KEGG pathways. These scores indicate which GO terms or KEGG pathways the drug targets. The feature selection method, minimum redundancy maximum relevance, was used to analyze these GO terms and KEGG pathways and to identify important GO terms and pathways, such as sodium-independent or

SUBMITTER: Zhang YH 

PROVIDER: S-EPMC5079577 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature