Correlates of Medication Adherence in the TODAY Cohort of Youth With Type 2 Diabetes.

ABSTRACT:

Objective

To identify factors that predict medication adherence and to examine relationships among adherence, glycemic control, and indices of insulin action in TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth).

Research design and methods

A total of 699 youth 10-17 years old with recent-onset type 2 diabetes and ≥80% adherence to metformin therapy for ≥8 weeks during a run-in period were randomized to receive one of three treatments. Participants took two study pills twice daily. Adherence was calculated by pill count from blister packs returned at visits. High adherence was defined as taking ≥80% of medication; low adherence was defined as taking <80% of medication. Depressive symptoms, insulin sensitivity (1/fasting insulin), insulinogenic index, and

SUBMITTER: Katz LL 

PROVIDER: S-EPMC5079608 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature