Error-related brain activity dissociates hoarding disorder from obsessive-compulsive disorder.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is associated with an abnormally large error-related negativity (ERN), an electrophysiological measure of error monitoring in response to performance errors, but it is unclear if hoarding disorder (HD) also shows this abnormality. This study aimed to determine whether the neurophysiological mechanisms underlying error monitoring are similarly compromised in HD and OCD.

Method

We used a visual flanker task to assess ERN in response to performance errors in 14 individuals with HD, 27 with OCD, 10 with HD+OCD, and 45 healthy controls (HC). Age-corrected performance and ERN amplitudes were examined using analyses of variance and planned pairwise group comparisons.

Results

A main effect of hoarding on ERN (p = 0.031) was obser

SUBMITTER: Mathews CA 

PROVIDER: S-EPMC5079649 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature