Critical evaluation of latanoprostene bunod in the treatment of glaucoma.

ABSTRACT: Latanoprostene bunod (LBN) is a novel nitric oxide-donating prostaglandin F_2α receptor agonist in clinical development for intraocular pressure lowering in open-angle glaucoma and ocular hypertension. Currently in Phase III clinical trials in the USA, European Union, and Japan, LBN has demonstrated promising efficacy while maintaining safety and tolerability. We review preclinical and clinical developmental efforts and evaluate the potential role of LBN monotherapy in the management of open-angle glaucoma and ocular hypertension. The current LBN clinical development program comprises eight trials, four of which have resulted in publication of complete methodology and outcomes. We additionally pool adverse events data to determine incidences across three pivotal studies. Evidence

SUBMITTER: Garcia GA 

PROVIDER: S-EPMC5079698 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature