Vaccine technologies: From whole organisms to rationally designed protein assemblies.

ABSTRACT: Vaccines have been the single most significant advancement in public health, preventing morbidity and mortality in millions of people annually. Vaccine development has traditionally focused on whole organism vaccines, either live attenuated or inactivated vaccines. While successful for many different infectious diseases whole organisms are expensive to produce, require culture of the infectious agent, and have the potential to cause vaccine associated disease in hosts. With advancing technology and a desire to develop safe, cost effective vaccine candidates, the field began to focus on the development of recombinantly expressed antigens known as subunit vaccines. While more tolerable, subunit vaccines tend to be less immunogenic. Attempts have been made to increase immunogenicity with the

SUBMITTER: Karch CP 

PROVIDER: S-EPMC5079805 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature