Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer.

ABSTRACT:

Background

Radioresistance of thoracic radiotherapy is a major bottleneck in the treatment of non-small cell lung cancer (NSCLC). Until now, there have been no effective biomarkers to predict the radiosensitivity.

Purposes

Based on miRNA profile screened from NSCLC cell lines with different radiosensitivity, this study was conducted to explore the correlation between plasma miRNAs and radiotherapy response in NSCLC patients, and to identify biomarkers of the radiosensitivity in NSCLC.

Methods

Differentially expressed genes were acquired from time-series gene expression profiles of radioresistant H1299 and radiosensitive H460 lung cancer cells (GSE20549). Potential miRNAs were screened from these differentially expressed genes by combining bioinformatics with GO analys

SUBMITTER: Chen X 

PROVIDER: S-EPMC5080326 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature