TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.

ABSTRACT: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses, but its significance in non-infectious diseases remains unclear. Here, we demonstrate that TREM-1 promotes cardiovascular disease by exacerbating atherosclerosis. TREM-1 is expressed in advanced human atheromas and is highly upregulated under dyslipidemic conditions on circulating and on lesion-infiltrating myeloid cells in the Apoe^-/- mouse model. TREM-1 strongly contributes to high-fat, high-cholesterol diet (HFCD)-induced monocytosis and synergizes with HFCD serum-derived factors to promote pro-inflammatory cytokine responses and foam cell formation of human monocyte/macrophages. Trem1^-/-Apoe^-/- mice exhibit substantially attenuate

SUBMITTER: Zysset D 

PROVIDER: S-EPMC5080444 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature