Ontology highlight
ABSTRACT:
SUBMITTER: Berger E
PROVIDER: S-EPMC5080445 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161027
Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in epithelial function are implicated in inflammatory and neoplastic diseases of the gastrointestinal tract. Here we report that mitochondrial function plays a critical role in maintaining intestinal stemness and homeostasis. Using intestinal epithelial cell (IEC)-specific mouse models, we show that loss of HSP60, a mitochondrial chaperone, activates the mitochondrial unfolded protein response (MT-UPR) and ...[more]