Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay.

ABSTRACT: Studying the effects of HIV infection on the host transcriptome has typically focused on protein-coding genes. However, recent advances in the field of RNA sequencing revealed that long non-coding RNAs (lncRNAs) add an extensive additional layer to the cell's molecular network. Here, we performed transcriptome profiling throughout a primary HIV infection in vitro to investigate lncRNA expression at the different HIV replication cycle processes (reverse transcription, integration and particle production). Subsequently, guilt-by-association, transcription factor and co-expression analysis were performed to infer biological roles for the lncRNAs identified in the HIV-host interplay. Many lncRNAs were suggested to play a role in mechanisms relying on proteasomal and ubiquitination pathways, ap

SUBMITTER: Trypsteen W 

PROVIDER: S-EPMC5080576 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature