Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.

ABSTRACT: The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.

SUBMITTER: Kuepfer L 

PROVIDER: S-EPMC5080648 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature