Reorganization of Sleep by Temperature in Drosophila Requires Light, the Homeostat, and the Circadian Clock.

ABSTRACT: Increasing ambient temperature reorganizes the Drosophila sleep pattern in a way similar to the human response to heat, increasing daytime sleep while decreasing nighttime sleep. Mutation of core circadian genes blocks the immediate increase in daytime sleep, but not the heat-stimulated decrease in nighttime sleep, when animals are in a light:dark cycle. The ability of per(01) flies to increase daytime sleep in light:dark can be rescued by expression of PER in either LNv or DN1p clock cells and does not require rescue of locomotor rhythms. Prolonged heat exposure engages the homeostat to maintain daytime sleep in the face of nighttime sleep loss. In constant darkness, all genotypes show an immediate decrease in sleep in response to temperature shift during the subjective day, implying that

SUBMITTER: Parisky KM 

PROVIDER: S-EPMC5080662 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature