TRIg: a robust alignment pipeline for non-regular T-cell receptor and immunoglobulin sequences.

ABSTRACT:

Background

T cells and B cells are essential in the adaptive immunity via expressing T cell receptors and immunoglogulins respectively for recognizing antigens. To recognize a wide variety of antigens, a highly diverse repertoire of receptors is generated via complex recombination of the receptor genes. Reasonably, frequencies of the recombination events have been shown to predict immune diseases and provide insights into the development of immunity. The field is further boosted by high-throughput sequencing and several computational tools have been released to analyze the recombined sequences. However, all current tools assume regular recombination of the receptor genes, which is not always valid in data prepared using a RACE approach. Compared to the traditional multiplex PCR app

SUBMITTER: Hung SJ 

PROVIDER: S-EPMC5080739 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature