Decreased absorption of midazolam in the stomach due to low pH induced by co-administration of Banha-sasim-tang.

ABSTRACT:

Objectives

Banha-sasim-tang (BST), which consists of seven different herbs, is one of the most popular herbal formulae for treating gastrointestinal disorders in Eastern Asia. The commonly used herbal medicine is often co-administered with other therapeutic drugs, which raises the possibility of herb-drug interactions and may modify the clinical safety profile of therapeutic drugs.

Methods

We investigated the potential herb-drug interactions between BST extract and midazolam (MDZ) in mice. The area under the plasma concentration-time curve (AUC) of MDZ and 1ʹ-hydroxymidazolam (1ʹ-OH-MDZ) was evaluated for both oral and intraperitoneal administration of MDZ, following oral administration of BST (0.5 and 1 g/kg).

Results

It was found that the AUC of MDZ and 1ʹ-OH-MDZ wa

SUBMITTER: Jo JH 

PROVIDER: S-EPMC5080787 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature