Novel equine tissue miRNAs and breed-related miRNA expressed in serum.

ABSTRACT:

Background

MiRNAs regulate multiple genes at the post-transcriptional level and therefore play an important role in many biological processes. It has been suggested that miRNA exported outside the cells contribute to inter-cellular communication. Consequently, circulating miRNAs are of particular interest and are promising biomarkers for many diseases. The number of miRNAs annotated in the horse genome is much lower compared to model organisms like human and mouse. We therefore aimed to identify novel equine miRNAs for tissue types and breed in serum.

Results

We analysed 71 small RNA-seq libraries derived from nine tissues (gluteus medius, platysma, masseter muscle, heart, liver, cartilage, bone, total blood and serum) using miRDeep2 and miRdentify tools. Known miRNAs repres

SUBMITTER: Pacholewska A 

PROVIDER: S-EPMC5080802 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature