Association of Body Composition With Survival and Locoregional Control of Radiotherapy-Treated Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Importance

Major weight loss is common in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy (RT). How baseline and posttreatment body composition affects outcome is unknown.

Objective

To determine whether lean body mass before and after RT for HNSCC predicts survival and locoregional control.

Design, setting, and participant

Retrospective study of 2840 patients with pathologically proven HNSCC undergoing curative RT at a single academic cancer referral center from October 1, 2003, to August 31, 2013. One hundred ninety patients had computed tomographic (CT) scans available for analysis of skeletal muscle (SM). The effect of pre-RT and post-RT SM depletion (defined as a CT-measured L3 SM index of less than 52.4 cm2/m2 for men and less

SUBMITTER: Grossberg AJ 

PROVIDER: S-EPMC5080910 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature