Ontology highlight
ABSTRACT:
SUBMITTER: Chumbley CW
PROVIDER: S-EPMC5080977 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chumbley Chad W CW Reyzer Michelle L ML Allen Jamie L JL Marriner Gwendolyn A GA Via Laura E LE Barry Clifton E CE Caprioli Richard M RM
Analytical chemistry 20160205 4
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) elucidates molecular distributions in thin tissue sections. Absolute pixel-to-pixel quantitation has remained a challenge, primarily lacking validation of the appropriate analytical methods. In the present work, isotopically labeled internal standards are applied to tissue sections to maximize quantitative reproducibility and yield accurate quantitative results. We have developed a tissue model for rifampicin (RI ...[more]