Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.

ABSTRACT:

Importance

Although multiple HLA alleles associated with multiple sclerosis (MS) risk have been identified, genotype-phenotype studies in the HLA region remain scarce and inconclusive.

Objectives

To investigate whether MS risk-associated HLA alleles also affect disease phenotypes.

Design, setting, and participants

A cross-sectional, case-control study comprising 652 patients with MS who had comprehensive phenotypic information and 455 individuals of European origin serving as controls was conducted at a single academic research site. Patients evaluated at the Multiple Sclerosis Center at University of California, San Francisco between July 2004 and September 2005 were invited to participate. Spinal cord imaging in the data set was acquired between July 2013 and March

SUBMITTER: Isobe N 

PROVIDER: S-EPMC5081075 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature