Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis.

ABSTRACT:

Purpose

There is a need for improved subclassification of urothelial carcinoma (UC) at diagnosis. A major aim of this study was to search for novel genomic subgroups.

Experimental design

We assessed 160 tumors for genome-wide copy number alterations and mutation in genes implicated in UC. These comprised all tumor grades and stages and included 49 high-grade stage T1 (T1G3) tumors.

Results

Our findings point to the existence of genomic subclasses of the "gold-standard" grade/stage groups. The T1G3 tumors separated into 3 major subgroups that differed with respect to the type and number of copy number events and to FGFR3 and TP53 mutation status. We also identified novel regions of copy number alteration, uncovered relationships between molecular events, and elucidated

SUBMITTER: Hurst CD 

PROVIDER: S-EPMC5081094 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature