IgG subclasses determine pathways of anaphylaxis in mice.

ABSTRACT:

Background

Animal models have demonstrated that allergen-specific IgG confers sensitivity to systemic anaphylaxis that relies on IgG Fc receptors (FcγRs). Mouse IgG_2a and IgG_2b bind activating FcγRI, FcγRIII, and FcγRIV and inhibitory FcγRIIB; mouse IgG₁ binds only FcγRIII and FcγRIIB. Although these interactions are of strikingly different affinities, these 3 IgG subclasses have been shown to enable induction of systemic anaphylaxis.

Objective

We sought to determine which pathways control the induction of IgG₁-, IgG_2a-, and IgG_2b-dependent passive systemic anaphylaxis.

Methods

Mice were sensitized with IgG₁, IgG_2a, or IgG_2b anti-trinitrophenyl mAbs and challenged with t

SUBMITTER: Beutier H 

PROVIDER: S-EPMC5081282 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature