Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

ABSTRACT:

Objective

The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehydrogenase (G6PDH) activity in the pathogenesis of insulin resistance in skeletal muscle.

Methods

Multiple mouse disease states exhibiting insulin resistance and glucose intolerance, as well as obese humans defined as insulin-sensitive, insulin-resistant, or pre-diabetic, were examined.

Results

We identified increased glucose-6-phosphate dehydrogenase (G6PDH) activity as a common intracellular adaptation that occurs in parallel with the induction of insulin resistance in skeletal muscle and is present across animal and human

SUBMITTER: Lee-Young RS 

PROVIDER: S-EPMC5081409 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature