Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.

ABSTRACT:

Objective

The transcription factor cyclic AMP-responsive element-binding protein H (CREBH, encoded by Creb3l3) is highly expressed in the liver and small intestine. Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibroblast growth factor 21 (Fgf21) expression. However, the intestinal CREBH function remains unknown.

Methods

To investigate the influence of intestinal CREBH on cholesterol metabolism, we compared plasma, bile, fecal, and tissue cholesterol levels between wild-type (WT) mice and mice overexpressing active human CREBH mainly in the small intestine (CREBH Tg mice) under different dietary conditions.

Results

Plasma cholesterol, hepatic lipid, and cholesterol crystal formation in the gallbladder were lower in CREBH

SUBMITTER: Kikuchi T 

PROVIDER: S-EPMC5081412 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature