Functional connectivity in cortico-subcortical brain networks underlying reward processing in attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Many patients with attention-deficit/hyperactivity disorder (ADHD) display aberrant reward-related behavior. Task-based fMRI studies have related atypical reward processing in ADHD to altered BOLD activity in regions underlying reward processing such as ventral striatum and orbitofrontal cortex. However, it remains unclear whether the observed effects are region-specific or related to changes in functional connectivity of networks supporting reward processing. Here we use resting-state fMRI to comprehensively delineate the functional connectivity architecture underlying aberrant reward processing in ADHD.

Methods

We assessed resting-state functional connectivity of four networks that support reward processing. These networks showed high spatial overlap with the de

SUBMITTER: Oldehinkel M 

PROVIDER: S-EPMC5081416 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature