Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice.

ABSTRACT:

Objectives

Obesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of various diseases, modeling atherosclerosis in mice has proven difficult. Specifically, wild-type (WT) mice are resistant to developing atherosclerosis, while commonly used genetically modified mouse models of atherosclerosis are poor mimics of human disease. The lack of a physiologically relevant experimental model of atherosclerosis has hindered the understanding of mechanisms regulating disease development and progression as well as the development of translational therapies. Recent evidence suggests that housing mice within their the

SUBMITTER: Giles DA 

PROVIDER: S-EPMC5081423 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature