Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining.

ABSTRACT: Microbial natural products are an evolved resource of bioactive small molecules, which form the foundation of many modern therapeutic regimes. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a class of natural products which have attracted extensive interest for their diverse chemical structures and potent biological activities. Genome sequencing has revealed that the vast majority of genetically encoded natural products remain unknown. Many bioinformatic resources have therefore been developed to predict the chemical structures of natural products, particularly nonribosomal peptides and polyketides, from sequence data. However, the diversity and complexity of RiPPs have challenged systematic investigation of RiPP diversity, and consequently the vast maj

SUBMITTER: Skinnider MA 

PROVIDER: S-EPMC5081660 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature